Towards Atomistic Simulations of Eucariotic Chromatine: the nucleosome
|Principal Investigator(s)||Modesto Orozco|
|Leading Institution||Instituto Nacional de Bioinform�tica|
|DEISA Home Site||BSC|
We proposed to use DEISA-resources to perform a land-mark molecular dynamics study of the structure of two nucleosomes: a highly positioned nucleosome for which a crystal structure is available, and an artificial nucleosome created by substituting the DNA sequence in the crystal structure of Richmond and coworkers by a AATT rich sequence that is known to largely disfavour nucleosome formation. These extremely time consuming simulations will enable us to gain insight into the complex rules that guide the nucleosome positioning in the cromatine.