Blood in motion
|Research Area||Bio Sciences|
|Principal Investigator(s)||Prof.Dr. Federico Toschi|
Blood is a specialized body fluid that delivers necessary substances to the body’s cells while transporting waste products away. From a fluid mech
anical point of view, blood is characterized by extraordinary rheological properties due to the presence of a massive volume fraction of highly deformable
erythrocytes (red blood cells). The presence of red blood cells gives blood its remarkable non-Newtonian fluid properties, which allow an efficient transpo
rt of oxygen, nutrients, and cells from large arteries (>1cm in diameter) to the complex network of small capillaries (5-10 μm in diameter). In order to
understand thrombus formation (i.e. initiation and growth) the knowledge of local hemodynamics is fundamental. We plan a detailed investigation of the pla
sma and erythrocyte dynamics by means of direct numerical simulations which resolve the flow field as well as the individual cells. We aim at studying the
highresolution, long-time dynamics of both plasma and cells.
Our goals are to investigate in detail the dynamics of plasma between red blood cells, to record and study the time behavior of red blood cells, as well as to correlate the behavior of close-by red blood cells amongst themselves and with local p lasma properties. Further, we will study the resulting non-Newtonian flow and characterize it in terms of an effective viscosity also in relation with the local flow and cell/clogging configurations.